From Core Set to Assemblage

On the Dynamics of Exclusion and Inclusion in the Failure to Derive Beta Cells from Stem Cells

Abstract

**From Core Set to Assemblage: On the Dynamics of Exclusion and Inclusion in the Failure to Derive Beta Cells from Embryonic Stem Cells** In this paper, we examine the controversy surrounding the Lumelsky protocol (which potentially could have transformed the procedures for differentiating embryonic stem cells into beta cells for diabetes treatment). The protocol is analyzed initially using Collins’ core set model to show how the controversy over epistemic claims was resolved (and the Lumelsky protocol deemed to be a failure). This approach is then contrasted to an analysis in terms of scientific ‘assemblages’ characterized not by the resolution of epistemic controversy, but by the ‘irresolution’ or openness of social associations amongst scientists. We suggest that scientists who jumped on the ‘Lumelsky bandwagon’ can be rehabilitated, partly because of the recognized chronic uncertainty in the stem cell fi eld. Thus, alongside the judgement, resolution and exclusion mapped by core set analysis, there is ‘understanding’, irresolution and inclusion suggested by ‘assemblage analysis’. *Key words*: core set, assemblage, stem cells